Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6901 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
filingDate |
1998-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2004-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8505797bc5048d4f1568afba8a43206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c0f5fe173917d5a9726f303c9d219a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15e8d6cc86f2508cbf4c4f1d45fe0eea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81cc5a5281303227d23e69614ccd3ad7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa72ba7990060f8aa2cae7c38d864eff |
publicationDate |
2004-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6818627-B1 |
titleOfInvention |
Functional fragments of HIV-1 Vpr protein and methods of using the same |
abstract |
Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010099112-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005117556-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003407-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003077826-A1 |
priorityDate |
1997-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |