| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b45180365a29ab24a097c55d7d4192e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 |
| filingDate |
2000-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aa53e0b3c0af50fc2b9795c8d2a615d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8b0d2f1b6534f8a6d081eaf3751de5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a40b0b3ec19b2694d3fc6416e20f5697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_851a03244d6d78f66d1fe9043be449e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c312895797595f98bbef4e7da1f39d8 |
| publicationDate |
2004-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6815465-B1 |
| titleOfInvention |
Heterocyclic compounds inhibiting angiogenesis |
| abstract |
The invention relates to compounds of general formula (I) wherein R stands for a group of general formula —COOR 1 , —CONR 2 R 3 , —CONR 4 CONR 4 R 5 or —CH 2 OR 6 , wherein R 1 stands for a C 2-6 alkyl group; a C 1-6 alkyl group substituted; or a C 3-6 cycloalkyl group; R 2 and R 3 are identical or different and stand independently from each other for hydrogen atom or a C 1-6 alkyl group which optionally may be substituted; a 5- or 6-membered cycloalkyl or a heteroaryl group; and their tautomers, solvates and the mixtures thereof and acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising compounds of general formula (I) as active agent. The angiogenesis-inhibitors according to the invention inhibit the neovascularization in living tissues and as such can be used for preventing and inhibiting angiogenesis appearing in connection with tumor growth and for preventing the formation of tumor metastases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004132722-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009141786-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009286291-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007065920-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009141786-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8440217-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7560252-B2 |
| priorityDate |
1999-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |