| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33a22e901d22b688239b0b3079b14837 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-922 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-44 |
| filingDate |
2000-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d446b9306d905633d7240fbbc9b69e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42aacb262c6fd389cfe59576e5691883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c0bbb62e8a8485099b59cc666e90588 |
| publicationDate |
2004-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6808936-B1 |
| titleOfInvention |
Methods and compositions for use in the diagnosis and treatment of chronic immune disease |
| abstract |
Methods and compositions are provided for use in the diagnosis and treatment of a host suffering from a chronic immune disease. In the diagnostic methods of the subject invention, a host derived sample, typically PBMC or a derivative thereof is assayed for the presence of low molecular weight fragments of RNase L, typically in conjunction with an evaluation of caspase activity. The results of this assay are then employed to diagnose and/or characterize a chronic immune disease in the host. In the treatment methods of the subject invention, an effective amount of agent capable of enhancing RNase L homodimer activity in the host, e.g., in host PBMC, is administered to the host. Also provided are methods for identifying agents having RNase L cleavage-inhibitory activity or RNase L fragment antagonist activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003017492-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7618560-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7686983-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7759086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008193957-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009231589-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007172834-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6989239-B2 |
| priorityDate |
2000-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |