http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6806376-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2002-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a02a19757b09826fc9edcc59ae2d0d |
| publicationDate | 2004-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6806376-B2 |
| titleOfInvention | Method for the preparation of citalopram |
| abstract | The invention relates to a method for the preparation of citalopram comprising, in either order, subjecting a compound of formulawherein Y is a cyano group or a group which may be converted to a cyano group, R is hydrogen, -O-R<1>, NH2, NHCH3 or -N(CH3)2 wherein R<1 >is selected from hydrogen, alkyl, alkenyl, alkynyl and optionally alkyl substituted aryl or aralkyl; toi) reduction of the double bond in the side chain of formula -CH=CH-COR:ii) conversion of the group-COR or a reduced form thereof to a dimethylaminomethyl group; andiii) if Y is not cyano, conversion of the group Y to a cyano group;followed by isolation of citalopram base or a pharmaceutically acceptable acid addition salt thereof. |
| priorityDate | 2000-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 184.