| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate |
2002-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df7eb580007ceaaddbc698582abf981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7d7394564413c24980cfda82475bf06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a85d830a7e5d4f8424bab128957533f |
| publicationDate |
2004-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6794502-B2 |
| titleOfInvention |
Methods for removing dimethoxytrityl groups from oligonucleotides |
| abstract |
The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5'-OH protecting group at the 5'-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5'-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides. |
| priorityDate |
1999-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |