| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbb7c566de48ddc2f6ab493710ddc328 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate |
2002-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeb0d331fec8bb580aae6c60545d0299
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1d57add7bed214b3e928229f22fbfc8 |
| publicationDate |
2004-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6777402-B2 |
| titleOfInvention |
Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture |
| abstract |
High purity pharmaceutical-grade water-soluble porphyrin derivatives given by formula 1 or 2 in the specification, and new methods to prepare and use such porphyrin derivatives are disclosed. A preferred method comprises the steps of one- or two-step direct acidic alcoholysis of biological raw material producing a crystalline alkyl pheophorbide, conversion of the obtained alkyl pheophorbide into an acidic porphyrin, and reaction of the acidic porphyrin in water or in an aqueous organic solution with a hydrophilic organic amine. Another preferred method comprises reaction of acidic porphyrins prepared in water or in aqueous organic solution with a hydrophilic organic amine. Another preferred method comprises the additional step of purification of the resultant water-soluble porphyrin derivative by reversed phase chromatography using volatile solvents. The disclosed compounds are useful as photosensitizers for the photodynamic therapy of cancer, infectious and other diseases as well as for light irradiation treatments in other cases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009326434-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7271164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2490273-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9216166-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005054635-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008139524-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007299046-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8187824-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007064842-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007064842-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019117604-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8546088-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8207329-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009075295-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7633007-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008029155-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009227553-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9417245-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005163821-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8980565-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004077621-A1 |
| priorityDate |
2001-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |