| abstract |
Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formulawhereinR<1>, R<2 >and R<2a >are independently hydrogen, OH, OR<5>, alkyl, -OCHF2, -OCF3, -SR<5a >or halogen;R<3 >and R<4 >are independently hydrogen, OH, OR<5b>, alkyl, cycloalkyl, CF3, -OCHF2, -OCF3, halogen, -CONR<6>R<6a>, -CO2R<5c>, -CO2H, -COR<6b>, -CH(OH)R<6c>, -CH(OR<5d>)R<6d>, -CN, -NHCOR<5e>, -NHSO2R<5f>, -NHSO2Aryl, -SR<5g>, -SOR<5h>, -SO2R<5i>, or a five, six or seven membered heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO2, or R<3 >and R<4 >together with the carbons to which they are attached form an annelated five, six or seven membered carbocycle or heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO2;R<5>, R<5a>, R<5b>, R<5c>, R<5d>, R<5e>, R<5f>, R<5g>, R<5h >and R<5i >are independently alkyl;R<6>, R<6a>, R<6b>, R<6c >and R<6d >are independently hydrogen, alkyl, aryl, alkylaryl or cycloalkyl, or R<6 >and R<6a >together with the nitrogen to which they are attached form an annelated five, six or seven membered heterocycle which may contain 1 to 4 heteroatoms in the ring which are N, O, S, SO, and/or SO2.A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above complex alone or in combination with another antidiabetic agent or other therapeutic agent. |