| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_374bd30b140c412aedda14571cbbc4a7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 |
| filingDate |
2000-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a79ac1c2bcda2143f563bf44c50a242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_837d0c0729a48bcad48d086119115bb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cff92dd109d28b63828fb4d41b6dc975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8943e129e7be5d6d1f4af7b811ce628
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8244cc28db5dc583df887ef167a34f11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8d2e421dc1310ad31957f0b0e30fae5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d40a61491c3522907f646653f51482f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4bade7700e0e6c631dbda7ff3110ee8 |
| publicationDate |
2004-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6774103-B1 |
| titleOfInvention |
Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors) |
| abstract |
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9334256-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2970964-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012101388-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012174488-A3 |
| priorityDate |
1997-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |