| abstract |
An objective of the present invention is to provide highly water-soluble compounds having integrin alphavbeta3 antagonistic activity. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts or solvates thereof:wherein A represents a two nitrogen atom-containing optionally substituted saturated or unsaturated five- to seven-membered heterocyclic group, which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a bicyclic group, or -C(-NR<1>R<2>)(=NR<3>) wherein R<1>, R<2>, and R<3 >represent hydrogen, alkyl or the like; D represents a bond, >NR<4>, wherein R<4 >represents hydrogen or optionally substituted alkyl, -O-, or -S-; X and Z represent either CH or N; R<7 >and R<8 >represent C1-6 alkyl, halogen, oxygen or the like; Q represents >C=O, >CHR<13 >or >CHOR<13 >wherein R<13 >represents hydrogen or alkyl; R<9 >represents hydrogen, alkyl or the like; J represents a bond or alkylene having 1 to 3 carbon atoms; R<10 >and R<11 >represent hydrogen, alkyl or the like; m is an integer of 0 to 5; n is an integer of 0 to 4; and p and q are an integer of 1 to 3. |