| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a947c5b565bf9b9919794f03db37eca |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 |
| filingDate |
2003-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0979523fa5969ab3e9bb2c29dd0e2283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b3794fcdf8286a724c5e5e2eacbf280
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95a7d50467b471923820afd1b27fcd81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063ae1112a20c146395d817762b396c4 |
| publicationDate |
2004-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6747163-B2 |
| titleOfInvention |
Method for the isolation of 6α, 9α-difluoro-11β, 17α-dihydroxy-16α-methylpregna-3-oxo-1,4-diene-17β-carboxylic acid |
| abstract |
The invention provides a process for the preparation and isolation of compound of formula 2, comprising the following steps:oxidizing Flumethasone dissolved in a tetrahydrofuran-water mixture with periodic acid at a temperature lower than 30° C.; cooling the reaction mixture to a temperature lower than 10° C.; adding an antisolvent precooled to a temperature lower than 10° C.; and separating the precipitated crystal by filtration, whereby there is obtained a compound of formula 2 in a yield of at least 98% and of a chromatographic purity of at least 99%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006019937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006011148-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006011148-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004209854-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7214807-B2 |
| priorityDate |
2002-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |