| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H01J49-165 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01J49-04 |
| filingDate |
2001-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65bf4763d14b3e8b4dc3e266a32b98a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad2223763177491067538ab6aeef5779
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5d9369dca51b20977bd55ce2bee4ab2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00162575040044257c0e7e189560e7f1 |
| publicationDate |
2004-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6727497-B2 |
| titleOfInvention |
Charge reduction in electrospray mass spectrometry |
| abstract |
The charge state of ions produced by electrospray ionization is reduced in a controlled manner to yield predominantly singly charged ions through reactions with bipolar ions generated using a 210 Po alpha particle source or equivalent. The multiply charged ions generated by the electrospray undergo charge reduction in a charge reduction chamber. The charge-reduced ions are then detected using a commercial orthogonal electrospray TOF mass spectrometer, although the charge reduction chamber can be adapted to virtually any mass analyzer. The results obtained exhibit a signal intensity drop-off with increased oligonucleotide size similar to that observed with MALDI mass spectrometry, yet with the softness of ESI and without the off-line sample purification and pre-separation required by MALDI. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11183376-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004031918-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011089037-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7078679-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7250138-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007102634-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004169137-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9905406-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7256396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10564137-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003199100-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7518108-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10043646-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007044153-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005109856-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8637812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11320409-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003202920-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008111066-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010271631-A1 |
| priorityDate |
1998-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |