| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114bf026be92e967a0de2428605a85b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00599
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00596
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00725
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00722
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2458-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00581 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B20-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6845
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B70-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-10 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B70-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-00 |
| filingDate |
1999-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71f15f1033afeb821c769abb643a1d08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0691ea2639f01e968496bf0b9622ff4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67074fe4a9361504840c324d72bc92d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c73d08e08c38ffdf91d2047f379273e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db09ce752790aa119781530be80b50e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb0095c45afd469b454a5215ab72876 |
| publicationDate |
2004-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6714875-B1 |
| titleOfInvention |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation |
| abstract |
The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups. Methods of use of the mass-coded combinatorial library produced by this method for identifying a ligand to a particular biomolecule are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8956824-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003032054-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7166475-B2 |
| priorityDate |
1998-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |