| abstract |
The present invention is directed to labeled compounds, [<2>H1, <13>C], [<2>H2, <13>C] and [<2>H3, <13>C]methyl aryl sulfides wherein the <13>C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structurewherein R1, R2, R3, R4, and R5 are each independently, hydrogen, a C1-C4 lower alkyl, a halogen, an amino group from the group consisting of NH2, NHR and NRR' where R and R' are each a C1-C4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [<2>H1, <13>C], [<2>H2,<13>C] and [<2>H3, <13>C]methyl aryl sulfides wherein the <13>C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [<2>H1, <13>C]methyl iodide and [<2>H2, <13>C]methyl iodide. |