http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6706890-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c3abccac7bae9414dc8ce09b2d192dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 |
| filingDate | 2000-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_533c62aaccb0961097d351b3b01f4349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adbfb5eb762ee4ffb06fd53b9866dda8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d38cb3bfc26689b5993db2e575a988cc |
| publicationDate | 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6706890-B2 |
| titleOfInvention | Method for producing oxindoles |
| abstract | The invention relates to a method for producing 2-oxindoles from the corresponding isatines of formula (I), wherein R can be H, CH3, phenyl or benzyl and R1 can be H, C1-C4-alkyl, C1-C4-alkoxy, phenyl phenoxy, halogen, amino, nitro or hydroxy. Said isatines are converted by means of hydrazine hydrate in a polar solvent at a temperature of 15 to 185° C. to form a corresponding isatine hydrazone which directly undergoes further reaction to form the corresponding 2-oxindole of formula (II) by adding diazabicyclooctane and/or diazabicycloundecane and/or ethyldiisopropylamine as a catalyst in temperatures of 100 to 185° C., whereby the produced reaction water is distilled off. According to formula (II), R and R1 have the aforementioned definitions. The 2-oxindole is isolated from the reaction mixture by distilling off the solvent and by means of crystallisation. |
| priorityDate | 1999-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.