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filingDate 2000-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6706261-B1
titleOfInvention Compositions and methods comprising immunogenic muteins of interleukin-6
abstract Cytokines, including muteins thereof, which are biologically inactive in humans but remain immunogenic, are used in pharmaceutical compositions to promote a neutralizing immune response against native cytokines when administered to a subject in need thereof to treat homeostatic disorders and disorders associated with an overproduction of cytokines.
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