http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6696439-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 |
| filingDate | 2000-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73ac6d60ad1f15f4213a4baace21c9b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25f1fc9a5e50e30ae25dc407a65f74c8 |
| publicationDate | 2004-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6696439-B1 |
| titleOfInvention | 5-HT1F agonists |
| abstract | The present invention relates to substituted furo[3,2-b]pyridine compounds of formula I:or a pharmaceutical acid addition salt thereof; where;R isE-D is C=CH or CH-CH2;R<1 >is hydrogen or C1-C4 alkyl;R<2 >is hydrogen, halo, hydroxy, -NR<3>R<4>, -SR<3>, -C(O)R<3>, -C(O)MR<3>R<4>, -NR<3>SO2R<5>, -NHC(Q)NR<3>R<4>, -NHC(O)OR<3>, or -NR<3>C(O)R<5>;R<3>, R<4>, and R<5 >are independently hydrogen, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or -(CH2)naryl; or R<3 >and R<4 >combine, together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, piperazine, 4-substituted piperazine, morpholine, or thiomorpholine ring;n is 0, 1, 2, 3, 4, 5, or 6; andQ is O or S.The present invention further relates to pharmaceutical. formulations containing compounds formula I and to the use of compounds of formula I for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and treating and/or preventing migraine in a mammal. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2940022-A1 |
| priorityDate | 1999-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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