| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3c2e77f8dfda692ca527454d23ecc03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
1999-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ca33ceabb13403923776032bfd9440a |
| publicationDate |
2004-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6689362-B1 |
| titleOfInvention |
Method for treating T-lineage leukemias and lymphomas using a CD7-specific monoclonal antibody (TXU-7) linked to the pokeweed antiviral protein (PAP) |
| abstract |
Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are common leukemias in both children and adults. Current treatment strategies are inadequate and often result in patient toxicity and relapse. Accordingly, the need exists for a T-cell-specific immunotoxin with sufficient stability and efficacy to eliminate cell populations associated with various T-cell malignancies. The present invention addresses this concern by providing a biotherapeutic agent (e.g., an immunoconjugate or immunotoxin) comprising a monoclonal antibody (MoAb TXU-7) specific to mammalian T-cell/myeloid antigen CD7 linked to the pokeweed antiviral protein (PAP). The CD7 antigen is expressed on human T-lineage lymphoid cells and leukemic progenitor cells in T-lineage lymphoid malignancies. PAP is a member of the hemitoxin group of toxins and inactivates ribosomes by the removal of a single adenosine from the conserved loop sequence found near the 3' terminus of all larger RNAs. This specific depurination abrogates the ability of elongation factors to interact with ribosomes and results in irreversible shut-down of protein synthesis. The PAP toxin was linked to the TXU-7 Mab to produce a TXU-7-PAP immunoconjugate. This immunotoxin is stable in vivo and effective in killing and eliminating CD7-expressing T-lineage leukemic cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017004144-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016210108-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016057398-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3954373-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3903829-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3912643-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3586874-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4257134-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011068845-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015130416-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016172427-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012151199-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014092804-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035689-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015126548-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015200260-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3243527-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3009455-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006128941-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3470087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3939617-A1 |
| priorityDate |
1997-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |