| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-319 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate |
2002-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d8c883e920e5912db9a054d293cb4e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cf9dfb8a44e262403536ce4ece10d40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c709331e8363aca7a20aa3010f03282a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2fb304cb1c93d9d662b80552db3e9d7 |
| publicationDate |
2004-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6683166-B2 |
| titleOfInvention |
Modified internucleoside linkages (ii) |
| abstract |
The invention relates to novel modified oligonucleotides, the construction thereof, and their use in oligonucleotide-based therapies. More specifically, the invention is to novel oligonucleotides having modified internucleoside linkages which are resistant to nucleases, having enhanced ability to penetrate cells, and which are capable of binding target oligonucleotide sequences in vitro and in vivo. The modified oligonucleotides of the invention are particularly useful in oligonucleotide-based therapies utilizing the modified oligonucleotides to interrupt protein synthesis or transcription or to otherwise inactivate messenger RNA or double stranded DNA. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011104668-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841429-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236570-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085773-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011104667-A1 |
| priorityDate |
1992-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |