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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdb889245f19a86d1be3000396b0a561
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publicationDate 2004-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6677156-B2
titleOfInvention Non-adenoviral gene product-based complementing cells for adenoviral vectors
abstract The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
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