| abstract |
There is provided a compound represented by thegeneral formula (1):wherein Het represents an optionally substituted heterocyclic group; A1 and A2 each independently represent -CH=, etc.; A3 represents -CH2-, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are -CH=, A3 represents -CH2- or -SO2-, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof. |