http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6673560-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-204165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-815 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-581 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate | 1999-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_264f8a1c6d9fba00b8d62a21063aa8f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_832705bd4d407fb5bcde9163d90e0c6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_888c6fd441e4e97f405d325d6a5831e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6923e50c0e6b5d777cb8ca450db9d2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d961f9da746f31c9911f814ba3ec6968 |
| publicationDate | 2004-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6673560-B1 |
| titleOfInvention | Measurement of hydride using chemiluminescent acridinium compounds and applications thereof |
| abstract | The present invention discloses a method for the measurement of hydride using a chemiluminescent compound. The preferred chemiluminescent molecule is an acridinium compound. The source of hydride for the reduction of acridinium compound may be of chemical or biochemical origin, or the result of enzymatic catalysis. The chemical source of hydride, for example, might be metal hydrides, such as NaBH4. A biochemical source of hydride might be that derived from NADH, or NADPH, while an enzymatic source would be the class of oxidoreductases termed dehydrogenases which convert NADH or NADPH from NAD or NADP.There are numerous potential applications for acridinium compounds as chemiluminescent indicators of hydride. Any applied tests or diagnostic assays, in which hydride is either present at the onset of or generated through the course of a reaction, would benefit from the present invention. Such tests, which could encompass many different formats as discussed below in detail, may involve the quantitation or detection of metal hydrides, or enzyme cofactors such as NADH, NADPH, FMNH2, or FADH2. Of particular importance, are those diagnostic assays which might use dehydrogenases as reagents, indicators, diagnostic markers or as labels. Ethanol, for example, might be detected with acridinium ester chemiluminescence through the reaction of alcohol dehydrogenase on ethanol, said reaction producing NADH. As a label, dehydrogenase might be used in an ELISA for the detection of a specific analyte with acridinium ester providing the signaling response. Nucleic acid assays using dehydrogenase as a label are also envisioned. Assays for the detection of clinically relevant dehydrogenases such as elevated glutamate dehydrogenase as an indicator of hepatocellular damage might also be developed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014083427-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009029349-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015200182-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015200186-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008248493-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906293-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012028167-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112268896-A |
| priorityDate | 1998-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 546.