http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6664086-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78941ed5a01bfbcd48376e1fdb485b19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11022 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2002-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b35f2d1a89aab85970970f95ce5dcee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c2cecb12f9247666d2d13001680de3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44af8ee4acdd9fa1ad739cedb103854 |
| publicationDate | 2003-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6664086-B2 |
| titleOfInvention | cDNA, genomic, and predicted protein sequences of learning-induced kinases |
| abstract | To elucidate molecular mechanisms in learning and memory, the expression of mRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of the transcription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blocked learning but not performance of the CR. Differential display PCR (DD-PCR) analysis of cerebellar RNAs from trained and pseudo-trained rabbits identified a 207-bp band that was induced with learning. The fragment was used to isolate a cDNA from a lambdagt11 rabbit brain library containing a 1698-bp open-reading frame. The genomic sequence also has been obtained and is reported. The deduced amino acid sequence contains the KKIAMRE motif, which is conserved among cdc2-related kinases. These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory. |
| priorityDate | 1998-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 383.