http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6663892-B1

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-24
filingDate 2002-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e345af8a356e44b01b3de7d56397332
publicationDate 2003-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6663892-B1
titleOfInvention Multiple portion tablet
abstract A solid orally administrable pharmaceutical dosage form for the treatment of gastric disorders includes a first portion containing a therapeutically effective amount of a histamine H2-receptor antagonist, and a second portion immediately adjacent the first portion without an intervening barrier disposed between the first portion and the second portion, the second portion containing a therapeutically effective amount of an antacid. Physical separation of the active ingredients into two different portions without a separating barrier has been found sufficient to prevent degradation of the histamine H2-receptor antagonist due to contact with the antacid. The invention therefore provides stabilization of a histamine H2-receptor antagonist-antacid combination tablet which is comparable to known multiple portion tablets, but without an intervening barrier between the antacid portion and the histamine H2-receptor antagonist portion. Therefore, the benefits of the prior art are achieved at a reduced cost by eliminating a barrier and manufacturing steps associated with the provision of a barrier, as is conventional.
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