| abstract |
Described herein is a series of aryl piperazine compounds of the formula:whereinAr' is a mono or bicyclic aryl or heteroaryl radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C5)cycloalkyl, (C3-C8)cycloalkenyl or halo;R<1 >is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio;R<2 >is phenyl, naphthyl or (C3-C12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo;R<3 >is selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C5)cycloalkyl, (C3-C8)cycloalkenyl or halo;X is -(C=O)-, -CHOH- or -CH2-;or a pharmaceutically acceptable salt, racemate, optical isomer or solvate thereof. |