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filingDate 1999-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6660524-B1
titleOfInvention Control of gene expression in eukaryotes
abstract A chemically inducible gene expression system is described. A chimeric gene having a first sequence comprising a promoter and a regulator polypeptide is linked with a second sequence comprising a promoter and a coding or non-coding sequence. Expression of the target gene of the second sequence is controlled by the regulator polypeptide which is acted upon by an inducer. The inducer is a chemical compound, such as OHP, which acts upon the OHP responsive regulator polypeptide, which can be obtained from Rhodococcus sp. V49. Various domain regions and complementary response elements are also described.
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