| abstract |
We have synthesized a series of new derivatives of (2-azinylamino) quinone, that have the general formula shown below. Several compounds of this new series of derivatives have been shown to be inhibitors of 5-lipoxygenase, with minimal or no effect on cycloxygenase-1 and 2-(COX-1 and COX-2) activity.where:A is N, CH, or, CCl;B is N, CH, CCH3, or Cph;X is H, Cl, Br, or I;Y is H, or CH3;R<1 >is H, CH3, OCH3, or Ph; and R<2 >is H, CH3, OCH3, or Ph; or R<1>-R<2 >is (CH=CH)2; andR<3 >is H or CH3. |