| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2000-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0512fa6c4758ff8404712a69a6a29a7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fba28079ce4a93d1dc97c70a7437337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c97b2ec19f27a977b08a09a5c05d4f34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab09ae7e5d6739805dcab15259caa578 |
| publicationDate |
2003-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6653064-B1 |
| titleOfInvention |
Method for identifying compounds useful in the therapy of bone disorders |
| abstract |
The present invention relates to a screening method for identifying a substance for the treatment of bone disorders that are associated with reduced bone mass in which the substance is tested for its ability to upregulate the expression of Fra-1 or to modulate the expression of a Fra-1 target gene in osteoblasts where the upregulation or modulation results in an increased bone formation in vivo. The identified osteoinductive compounds and DNA molecules encoding biologically active Fra-1 molecules can be used for the therapy of bone disorders characterized by a circumscribed or systemic reduction of bone mass. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010015164-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8030270-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8026074-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109077832-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7833730-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007068003-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008146532-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8026212-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8217025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002077273-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7803753-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8486646-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7803754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8101626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007068003-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109122581-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6916603-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883714-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7838254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8198232-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816364-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8022034-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007072803-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007072804-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8580526-B2 |
| priorityDate |
1999-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |