http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6649637-B2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 |
| filingDate | 2002-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8013197e5a2cd4cea4ff52a54e15d820 |
| publicationDate | 2003-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6649637-B2 |
| titleOfInvention | Inhibition of intracellular replication by pyridinylimidazoles |
| abstract | Substituted pyridinylimidazoles SB203580 and SB202190 strongly inhibit replication and cause stage conversion from active tachyzoites to relatively dormant bradyzoites of the medically important, obligate intracellular parasite Toxoplasma gondii . The pyridinylimidazoles probably mediate these effects by acting on a presently unidentified homologue(s) of human p38-mitogen activated protein kinase present in the tachyzoites. SB203580 also significantly enhanced in vitro inhibition of T. gondii replication by the approved anti-Toxoplasma drug pyrimethamine. The pyridinylimidazoles and related compounds disclosed herein could thus be significant adjuncts to currently available therapies. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088915-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009186010-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010104536-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007128648-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007056771-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005043257-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7235654-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7838268-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112284-A1 |
| priorityDate | 2001-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 205.