http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6638975-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2518458cb1641e855357a4291a110ff0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-38 |
| filingDate | 2002-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a46a48db0fda254628d1670526288d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f4f43b7701199f834192b922d47f806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ffca4eedbca10fdbbe96bcca2fd8fef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_634d6ac96098aa94ed620d8a1ee81326 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d22ee6ecba4a201de3c5b64834980c3 |
| publicationDate | 2003-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6638975-B1 |
| titleOfInvention | Treatment of breast cancer |
| abstract | Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N'-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2). The invention also encompasses a class of the compounds with the novel property of anti-tumor activity against human breast cancer, which includes the following compounds 4-(4-Ethoxy-phenyl)-2-(N'-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid methyl ester (OF-13); 2-{N'-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester (OF-20); 2-(N'-Fluoren-9-ylidene-hydrazino)-4-oxo-4-phenyl-but-2-enoic acid methyl ester (1F-04); and 4-Chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9517240-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010160275-A1 |
| priorityDate | 2001-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 371.