| abstract |
Compounds of the formulawherein Ar is aryl, R<1 >and R<2 >are hydrogen alkyl, alkyl substituted with phenyl, and aryl, O, NH, NR<4 >and S, R<5 >is hydrogen, alkyl or aryl or alkylene when taken with R<1>, and R<3 >is hydrogen, alkyl, alkyl substituted with phenyl, aryl, a heterocyclic group or a polycyclic group, are antiviral agents. A typical embodiment is (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol O-[phenyl-(methoxy-L-alaninyl)]phosphate. |