| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0cf3371a9dd0e2fab14e900377fd1096 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2334-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-968 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5765 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-576
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K3-00 |
| filingDate |
2002-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e946f5060d99433071e2c4b12e8bcdc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f69c60be76c35776b09043693b09a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_624a7ebc0abc3c02783799aa8f6aaadd |
| publicationDate |
2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6635437-B2 |
| titleOfInvention |
Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes |
| abstract |
Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon-carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity. The novel chemiluminescent compounds and compositions are useful in methods for producing light and in assays for phosphatase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009246888-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011124965-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005272108-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008286856-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004266783-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008193956-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007037174-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009137666-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7879575-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7919019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011152116-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005186606-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7217527-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009137666-A3 |
| priorityDate |
1996-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |