| abstract |
A transdermal administrating device is provided which includes an active electrode having a conductive electrode layer and a conductive drug layer applied on the bottom surface of the conductive electrode layer. The bottom surface of the conductive drug layer is capable of being placed in contact with skin. The device also includes an inert electrode capable of being placed in contact with skin and spaced from the active electrode, a set of conductive electrode layers each having a different standard single electrode potential, and a controller for measuring an internal resistance of the skin tissue under the region between the conductive electrode layers and for controlling an electric current passing between the active electrode and the inert electrode based on the variation in the internal resistance. In addition, a dermocontact mechanism is provided for keeping the active electrode, the inert electrode, and the set of conductive electrode layers in contact with skin. |