http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6620616-B1

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-13039
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filingDate 2000-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c85d57f8603f8ae6bc201721bd18e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a349ee99a16c6a6c570b0b85dd36d76
publicationDate 2003-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6620616-B1
titleOfInvention Nucleic acids encoding nitric oxide synthase variants
abstract Isolated polynucleotides which encode a variant of a mammalian nitric oxide synthase protein or polypeptide are provided. The variant nitric oxide synthase protein and polypeptides are substitution mutants, wherein the tryptophan that is normally located on the alpha 3 helix, six residues upstream from the cysteine which binds heme in the corresponding non-variant nitric oxide synthase protein or peptide is replaced with one of the other 19 naturally-occurring amino acid residues. The present invention also relates to vectors and recombinant cells comprising a nucleic acid which encodes a variant of a mammalian nitric oxide synthase protein. The present invention also relates to the nitric oxide synthase variant proteins and polypeptides.
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priorityDate 2000-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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