http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6613880-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fc6c2e9e63b6561f2f46b1de31f6379 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2001-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_737f5982fb5a82657138e198372e783a |
| publicationDate | 2003-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6613880-B2 |
| titleOfInvention | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis |
| abstract | Non-peptidic compounds characterized by containing a segment condensed from pipecolic acid, aspartic acid, proline and threonine, or derivatives thereof, are useful to treat autoimmune diseases and inflammatory conditions. Compounds of particular interest are those of the formula:wherein R1 is phenyl or cyclohexyl; wherein R2 is hydrido or methyl; wherein R3 is selected from hydrido, hydroxy, acetylamino, acetyl(Lys/Tyr/Thr)NH-, propionylamino and benzyloxycarbonylamino; wherein R5 is selected from isopropyl, isobutyl, n-propyl, n-butyl, aminopropyl, aminobutyl, phenyl, benzyl, hydroxyphenyl, hydroxybenzyl, morpholinocarbonylethyl, morpholinocarbonylpropyl, piperazinocarbonylethyl, piperazinocarbonylpropyl, pyridinylcarbonylethyl, pyridinylcarbonylpropyl, oxazolylcarbonylethyl, oxazolylcarbonylpropyl, azepinylcarbonylethyl and azepinylcarbonylethyl; wherein R6 is selected from hydrido, methyl, hydroxy, methoxy, phenyl and aminocarbonyl; wherein R7 is carboxyl or methylthiomethyl; wherein R9 is selected from hydrido, hydroxy, methoxy and phenyl; wherein R12 is selected from methyl, ethyl, propyl, butyl, isobutyl, -CH(iBu)CH2OH and -CH(iBu)CONH2; or a pharmaceutically-acceptable amide, ester or salt thereof. A disease state of particular interest for use of the compounds would be rheumatoid arthritis. |
| priorityDate | 1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 972.