| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5e95156255d5fe8b2923c544786e176
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-04012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_befc86a891851e34dfaa0fc04ca55514
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b09afacaaecdac9b2f5af73268561b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31222f9cff15da01d7fa60373db62423 |
| publicationDate |
2003-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6613322-B2 |
| titleOfInvention |
Method for treating a subject suffering from conditions associated with an extracellular zinc sphingomyelinase |
| abstract |
The present invention provides for a method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase activity which comprises administering to the subject an amount of a zinc sphingomyelinase inhibitor effective to decrease extracellular zinc sphingomyelinase activity in the subject and thereby treat the subject. The present invention also provides for a method for determining whether a compound inhibits an activity of an extracellular zinc sphingomyelinase involving ceramide formation which comprises: (a) contacting a sample containing zinc sphingomyelinase under acidic pH conditions known to be associated with the activity of such zinc sphingomyelinase, with: (i) a substrate of the zinc sphingomyelinase enzyme, and (ii) the compound being evaluated; (b) measuring the ceramide in the sample from (a); (c) determining the amount of zinc sphingomyelinase activity in the sample based on the concentration of ceramide measured in step (b); and (d) comparing the amount of sphingomyelinase activity determined in step (c) with the amount of sphingomyelinase activity determined in the absence of the compound, so as to determine whether the compound inhibits the activity of zinc sphingomyelinase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361465-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9274130-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006171946-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8222373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871202-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008138334-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011020319-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8796429-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8025877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8026342-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010226916-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7956173-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008090303-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7794713-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7901682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8614103-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7862812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829674-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009074789-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8444970-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009010922-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006018882-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008145360-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005208090-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003096022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007281320-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9217749-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008027088-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007212348-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9274129-B2 |
| priorityDate |
1997-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |