| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_379a600b6d7f336a460fafea157cec22 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 |
| filingDate |
2000-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e86e0fc984237f5b435398c545b95759
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e2d1929502ae69270a21d481d3e3542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ebc6a53d21b6b311cd3a0230020419 |
| publicationDate |
2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6586188-B1 |
| titleOfInvention |
Method for identification of compounds that bind to β-tubulin and stimulate insulin secretion |
| abstract |
According to the invention β-tubulin, as well as a 65 kDa polypeptide present in pancreatic β-cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, thereby stimulating insulin secretion. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7265248-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006008864-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006148674-A1 |
| priorityDate |
1999-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |