http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6585676-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92c68df06ef0131e022649bd279738d5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-053 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3681 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-36 |
| filingDate | 2001-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6647a7d0e46191a4ba359419146761b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_287d2900acbc828a653a841dfda6a1fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b55ad3b2475a92eacf26a60524ef9ce |
| publicationDate | 2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6585676-B1 |
| titleOfInvention | UVC radiation therapy for chronic lymphocytic leukemia |
| abstract | Lymphocytes from chronic lymphocytic leukemia (CLL) patients have been found to be readily killed by ultra-violet light-C (UVC) radiation. Cells from healthy donors were minimally affected by doses of UVC 10 times higher than those which caused dramatic drops in the metabolism of CLL cells and eventual death. n Irradiated cells from CLL patients and from healthy individuals all demonstrated a number of single strand DNA breaks and alkali-labile sites compared to unirradiated control cells. The extent of DNA damage to both healthy and CLL cells is dose dependent. However, the CLL cells demonstrated more extensive DNA fragmentation and an inability to undergo self-repair. The heightened sensitivity to UVC radiation of lymphocytes from CLL patients is used to provide an excorporeal treatment of CLL lymphocytes followed by the re-introduction of the treated lymphocytes to the patient. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004137418-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6970740-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005058360-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010168823-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005256553-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005058360-A3 |
| priorityDate | 2000-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.