| abstract |
The invention relates to compounds of formula Iand of formula IIin which R1, R2, R3, R4, R5, X1, X2, X3, X4, X5 and Y are defined in the specification. The compounds of formulae I and II inhibit cyclin-dependent kinases (CDKS) and other kinases (KDR), have cytostatic actions, and are suitable for treating tumors. The compounds of formulae I and II are obtainable by extracting the plant Uvaria klaineri, PLA 100484, by cell cultures of the plant Uvaria klaineri, or by chemical synthesis. The invention relates to a method for preparing the compounds of formulae I and II, to the use of the compounds for producing a pharmaceutical for the treatment of malignant disorders and of diseases which may be treated by inhibition of CDKs and KDR, and also to pharmaceutical compositions comprising at least one compound of the formula I or II. |