| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8fb1456312aa7998c552f43f015e6bc |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 |
| filingDate |
1999-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b0195a887623acd6e49dc61303cf4f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1118f4247e18fa30269903a789da1185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76cf723d15bc7c38b123b6c594452696
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec6013762481eacf27b0e2d61c0efcd4 |
| publicationDate |
2003-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6573392-B1 |
| titleOfInvention |
Process for manufacturing simvastatin and the novel intermediates |
| abstract |
This invention describes the synthesis of simvastatin from lovastatin by converting the lovastatin to lova amide using a secondary amine and subsequent reaction with a metal amide base generated from n-butyl lithium and pyrrolidine and followed by treatment with methyl iodide to give desired C-methylated intermediate. This intermediate was further transformed to the final product, simvastatin. This method of production consumes lesser quantities of metal amide, gives fewer side reactions and a lowered overall cost of manufacture of simvastatin than other procedures reported. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10300041-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9597289-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009311330-A1 |
| priorityDate |
1999-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |