| abstract |
Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: n wherein: n R 1 is Ar or Het; n R 2 is H, C 1-6 alkyl or Ar—C 0-6 alkyl; n X is H, C 1-4 alkyl, OR′, SR′, C 1-4 alkylsulfonyl, C 1-4 alkylsulfoxyl, CN, N(R′) 2 , CH 2 N(R′) 2 , NO 2 , CF 3 , CO 2 R′, CON(R′) 2 , COR′, NR′C(O)R′, F, Cl, Br, I, or CF 3 S(O) r —; n R′ is H, C 1-6 alkyl or Ar—C 0-6 alkyl; and n r is 0, 1 or 2; n or a pharmaceutically acceptable salt thereof. |