http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6569684-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2518458cb1641e855357a4291a110ff0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 2001-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f53c40fde0c251c33ea3f7a3b0066914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0149fae4669d032aacdd89f7e01fbbb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebb54dfb77729d51b66af8088a3f92a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fdbc4508ba31b9d5973439179c6d1e7 |
| publicationDate | 2003-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6569684-B2 |
| titleOfInvention | Method of identifying and treating invasive carcinomas |
| abstract | Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010179072-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4008270-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011223109-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014160114-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3498862-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10792018-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10058306-B2 |
| priorityDate | 2000-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 202.