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filingDate 2001-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6566504-B2
titleOfInvention Process for viral inactivation of lyophilized blood proteins
abstract A process for inactivating viral contaminants of lyophilized Factor VIII by heat is provided. The process comprises forming a stable complex between the Factor VIII and a cyclodextrin in an aqueous solution. The solution is then lyophilized, and the Factor VIII/cyclodextrin complex is recovered. The lyophilized Factor VIII/cyclodextrin is then heated to 60° C. to inactivate any virus present. The material may then be reconstituted prior to administration to a patient.
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