Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_916075766043ce900399a4c2eee9f054 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2000-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2003-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c109b3351dc5e2e25a565a534087506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0349aeec21033364542316d07fbe702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fb81bd79b9cbf94955b469901e974ea |
publicationDate |
2003-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6563016-B1 |
titleOfInvention |
Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses |
abstract |
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and a amyloid encoding transgene. A method of screening for a compound which alters the rate or extent of amyloid deposition is additionally provided. The method consists of: (a) constructing a perlecan transgenic animal; (b) administering an effective amount of a test compound to said perlecan transgenic animal; and (c) determining whether said test compound alters the extent or rate of amyloid deposition. Finally, the invention provides a method of screening for a compound which alters the rate or extent of amyloid deposition. The method consists of: (a) constructing a perlecan/amyloid double-transgenic animal; (b) administering an effective amount of a test compound to said perlecan/amyloid double-transgenic animal; and (c) determining whether said test compound alters the extent or rate of amyloid deposition. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8754133-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007191330-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003017998-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004152760-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8163957-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004127555-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004260076-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7514583-B2 |
priorityDate |
1996-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |