| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_087bed7abab91ae0f927879f9fe8b273 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6839
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06182 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01T1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01T1-202
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2001-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d427a2897baf41bf617e420172b1e78 |
| publicationDate |
2003-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6555692-B1 |
| titleOfInvention |
Preparation and use of bifunctional molecules having DNA sequence binding specificity |
| abstract |
Novel small molecule polyamides that specifically bind with subnanomolar affinity to a predetermined sequence with potential use in molecular biology and human medicine are described. The designed compounds which target the minor groove of B-form double helical DNA offer a general approach for the control of gene-expression. Simple rules are disclosed which provide for rational control of the DNA-binding sequence specificity of synthetic polyamides containing N-methylpyrrole and N-methylimidazole amino acids. A series of molecular templates for polyamide design are disclosed which provide for small molecules which recognize predetermined DNA sequences with affinities and specificities comparable to sequence-specific DNA-binding proteins. The pyrrole-imidazole polyamides described herein represent a class of designed small molecules that can bind any predetermined sequence of double helical DNA. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009188002-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9630950-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008269138-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835480-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011059160-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018280541-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307401-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008133877-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006174364-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009042965-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7919583-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935530-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005009054-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759533-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3988671-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007031380-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3550033-A1 |
| priorityDate |
1996-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |