| abstract |
Antimicrobial compounds of formula I are disclosed:whereinX is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (-CONH-) linkages is replaced by -CRaRaRbNRc-;Ra, Rb, and Rc are each independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C1-C6)alkoxycarbonyl, aryl, or heterocycle; andR1 and R2 are each independently hydrogen, a saccharide, a lipid, a solubilizing agent, or a suitable protecting group;or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising such compounds or salts, and methods of using such compounds or salts to treat a bacterial infection. |