http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6541646-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7021163b729521289028313faa08a079 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2002-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02bb749bb83e17625b82453fc410a8a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c4602503c237e3bd7fbfeff8cf089c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d737f376203af8ac1af0568c6557f66 |
| publicationDate | 2003-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6541646-B2 |
| titleOfInvention | Method of preparing COX-2 inhibitors |
| abstract | The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1-C6) alkyl. The method is characterized in that it comprises the following steps: a) reacting a compound of general formula (III) with an acid of general formula R1CH2 COOH (III) in a water-free medium; b) reacting the resulting compound with a strong base in an aprotic solvent in order to obtain an intermediate cyclic compound which forms a compound of general formula (I) after dehydration; and c) isolating said resulting compound of general formula (I). |
| priorityDate | 1999-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 216.