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filingDate 2001-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ad6c3d6a9c87ede7eaafa48775a9cab
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publicationDate 2003-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6541514-B2
titleOfInvention Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids
abstract Novel methods are provided for the manufacture of 117mSn(Sn4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to 117mSn(Sn4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.
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