| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-76 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36 |
| filingDate |
2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27794084c6e4c71267283ec52f8dfc57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9c63542bf9a1e5a5ffaebb3e45851ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7136c582c0b8c722bf493145301faa0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c48832db68a97a9ab8b3bc582087ceb |
| publicationDate |
2003-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6521416-B1 |
| titleOfInvention |
Determination of the amount of hLHβ core fragment in a sample from a subject and uses thereof |
| abstract |
The present invention provides a method for predicting the likely timing of the onset of menopause for a perimenopausal female subject by determining the amount of hLHbetacf in a sample from the subject comprising the steps of: (a) contacting a sample from the subject with an antibody which specifically binds to hLHbetacf without substantially cross-reacting with hLH, hLHbeta or hLHbetacf, under conditions permitting formation of a complex between the antibody and hLHbetacf; (b) measuring the amount of complex formed, so as to thereby determine the amount of hLHbetacf in the sample; and (c) comprising the amount of hLHbetacf in the subject's sample determined in step (b) with either (i) the amount determined for known postmenopausal female subject or (ii) the amount determined for a sample from a known premenopausal female subject, wherein an amount of hLHbetacf in the sample similar to the amount of hLHbetacf in the known postmenopausal sample indicates temporal proximity to the onset of menopause, and an amount of hLHbetacf in the sample similar to the amount of hLHbetacf in the known premenopausal sample indicates temporal distance from the onset of menopause for the subject. AS described herein amount is both concentration and pattern of measurement of concentrations in one or more consecutive urine specimens. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9541563-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011189793-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004219621-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7439026-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7655410-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7229781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009104624-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003059842-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8753825-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7897362-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004058383-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8227197-B2 |
| priorityDate |
1998-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |