http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6498189-B1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a776308e51e2266a6e44c2e243c70233 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-285 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-285 |
filingDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2002-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ad8c3fff34ec8b2592ea1b69eeb4f22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a9c9a583bb3b5811a384d4071e456c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ba1dc2f0cc28098f0e788ceb33003ff |
publicationDate | 2002-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-6498189-B1 |
titleOfInvention | Method for induction of L-selectin shedding |
abstract | The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9333069-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9011534-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8647385-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3141249-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8221498-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007203499-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004267318-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7211111-B2 |
priorityDate | 1999-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 426.