| abstract |
A cyclic amine compound represented by the following general formula (1):wherein,R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group;W1 an W2 each independently represent N or CH;X represents O, NR4, CONR4 or NR4CO;R4 each independently represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroalkyl group; andl, m and n each represents a number of 0 to 1, a salt thereof and a hydrate thereof are provided.These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like. |